NK cell receptors: evolution and diversity
نویسندگان
چکیده
منابع مشابه
Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors.
Ly49 lectin-like receptors and killer cell Ig-like receptors (KIR) are structurally unrelated cell surface glycoproteins that evolved independently to function as diverse NK cell receptors for MHC class I molecules. Comparison of primates and various domesticated animals has shown that species have either a diverse Ly49 or KIR gene family, but not both. In four pinniped species of wild marine c...
متن کاملCommentary: “Can Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?”
In Ref. (1) and in the study of interest (2), Carrillo-Bustamante et al. investigate in silico whether the diversity of inhibitory NK receptors (iNKRs) can be explained by viral evasion mechanisms involving MHC downregulation. Inhibitory NK receptors on NK cells recognize Type I MHCs on healthy cells, maintaining NK cells in an inhibited state. Several viruses have the ability to downregulate M...
متن کاملCan Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?
Natural killer (NK) cells express inhibiting receptors (iNKRs), which specifically bind MHC-I molecules on the surface of healthy cells. When the expression of MHC-I on the cell surface decreases, which might occur during certain viral infections and cancer, iNKRs lose inhibiting signals and the infected cells become target for NK cell activation (missing-self detection). Although the detection...
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Plant cell walls display a considerable degree of diversity in their compositions and molecular architectures. In some cases the functional significance of a particular cell wall type appears to be easy to discern: secondary cells walls are often reinforced with lignin that provides durability; the thin cell walls of pollen tubes have particular compositions that enable their tip growth; lupin ...
متن کاملNK cell receptors: Of missing sugar and missing self
Natural killer cells in mice detect cells in distress using lectin-like receptors that bind to self-MHC class I molecules. A new co-crystal structure suggests how NK cell maturation and attack may be mediated by receptor interaction at two distinct sites on the MHC class I molecule, both involving glycosylation.
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/46021